Treatment Strategies in Chronic Leukemias and Introduction to CAR-T Therapy
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Release Date: January 24, 2018
Expiration Date: January 24, 2019
Chronic lymphocytic (CLL) and chronic myelogenous (CML) leukemia are commonly diagnosed and treated by community oncologists. Whereas, in the past, these hematologic malignancies were considered incurable, new therapies have challenged that notion.
Tyrosine kinase inhibitors (TKIs) annihilated the concept of CML as a poorly controlled disease, and most patients are now expected to live a normal life, with good quality of life. New testing procedures have suggested that some patients may be “cured,” such that ongoing chronic pharmaceutical intervention may be interrupted or discontinued. Identifying new targets in CLL has similarly changed the paradigm of intervention to the possibility of “cure” using a more aggressive and multiagent approach.
A new form of immunotherapy, using CAR-T cells, initially used in acute leukemias, now appears to be applicable to CLL as well, with encouraging results. New molecular tests to identify subsets of patients who may benefit from targeted interventions have also improved the chances of success in treating chronic leukemias. This webcourse will review new concepts in diagnosis and treatment of CLL and CML.
The primary audiences for this activity are:
- Community-based oncologists and hematologists; drivers of evidence-based practice changes, treatments, and care planning across multiple tumor types
- Oncology nurses, advanced practice nurse (APNs), registered nurses (RNs), and nurse practitioners (NPs); primary point persons for patient management and education
- Oncology, health-system, and managed-care pharmacists; responsible for dispensing cancer therapies, ensuring appropriate use, and including new agents on Formularies
- Oncology treatment-team members involved in managing patients with cancer and providing supportive services (e.g. financial advocates, nutrition plans, psychological assessment, genetic counseling, and navigation)
Saar Gill, MD, PhD
Assistant Professor of Medicine
Division of Hematology‐Oncology
University of Pennsylvania Perelman School of Medicine
Saar Gill, MD, PhD obtained his medical degree and PhD in immunology from the University of Melbourne in Australia, and completed a post-doctoral fellowship in cellular therapy at Stanford University. He is now an Assistant Professor of Medicine at the University of Pennsylvania, where he specializes in the treatment of patients with leukemia and in bone marrow transplantation.
Dr. Gill leads a clinical trial of chimeric antigen receptor (CAR) T cell trials for chronic lymphocytic leukemia. Dr. Gill’s research laboratory focuses on the interface between adoptive cellular therapy and genetic engineering.
At the conclusion of this session, participants should be able to demonstrate the ability to:
- Incorporate treatment pathways and quality measures to ensure patients receive guideline-consistent care
- Evaluate the sequential and combination administration of chemotherapy and targeted agents to optimize survival in patients with chronic leukemia
- Discuss current recommendations for diagnostic testing for chronic leukemia to facilitate treatment selection
- Assess the safety and efficacy of approved and emerging therapies for primary and subsequent management of chronic leukemia with attention to cost/benefit and toxicity considerations
- Employ resources to increase patient access and engagement
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Potomac Center for Medical Education and Rockpointe Oncology. The Potomac Center for Medical Education is accredited by the ACCME to provide continuing medical education for physicians.
Physician Credit Designation
The Potomac Center for Medical Education designates this enduring activity for a maximum of 1.00 AMA PRA Category 1 Credit TM. Physicians should claim only the credits commensurate with the extent of their participation in the activity.
The Potomac Center for Medical Education is accredited by the Accreditation Council for Pharmacy education as a provider of continuing pharmacy education.
Total number of CE credits made available at this conference is 1.0 hours (0.10 CEUs).
A statement of credit will be issued only upon receipt of a completed activity evaluation.
This is an application-based activity.
For questions regarding CME/CE credit, the post-test, evaluation, please email firstname.lastname@example.org.
Joint Accreditation Statement
In support of improving patient care, this activity has been planned and implemented by the Postgraduate Institute for Medicine, the Potomac Center for Medical Education, and Rockpointe Oncology. Postgraduate Institute for Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Continuing Nursing Education
The maximum number of hours awarded for this Continuing Nursing Education activity is 1.1 contact hours. Designated for 0.3 contact hours of pharmacotherapy credit for Advance Practice Registered Nurses.
The Potomac Center for Medical Education (PCME) adheres to the policies and guidelines, including the Standards for Commercial Support, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous.
All persons in a position to control the content of a continuing medical education program provided by PCME are required to disclose any relevant financial relationships with any commercial interest to PCME as well as to learners. All conflicts of interest are identified and resolved by PCME in accordance with the Standards for Commercial Support in advance of delivery of the activity to learners.
The content of this activity was vetted by an external reviewer to assure objectivity and that the activity is free of commercial bias.
The faculty and steering committee reported the following relevant financial relationships that they or their spouse/partner have with commercial interests:
Saar Gill, MD, PhD: Nothing to disclose
Non-faculty content contributors and/or reviewers reported the following relevant financial relationships that they or their spouse/partner have with commercial interests:
Chad Williamson, MS, MBA, CMPP; Shawna Graves, PhD; Blair St. Amand; Judi Smelker-Mitchek, RN, MSN, MBA; Trace Hutchinson, PharmD; Samantha Mattiucci, PharmD, CHCP; Jan Shultz, MSN, FACEHP, RN, CHCP; Lindsay Scott, PT, DPT, ATC: Nothing to disclose
Gary I. Cohen, MD: Speaker’s Bureau: Genzyme, NantHealth; Shareholder: Celgene
Alex Ganetsky, PharmD: Honoraria/Advisory Board: Jazz; Speaker’s Bureau: Amgen, Incyte
The content of some CME/CE activities may contain discussions of non-approved or off-label uses of some agents mentioned. Please consult the prescribing information for full disclosure of approved uses.
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Instructions for Participants and Obtaining CME/CE Credit
There is no fee for this activity. To receive credit, participants must take the pre-test, view this CME/CE activity in its entirety, and then complete the post-test, with a score of 70% or better, and evaluation. The estimated time for completion of this activity is 1.0 hour. To receive their certificates, participants must demonstrate mastery of the presented material via the post-test. Participant is allowed to take the post-test multiple times.
Jointly provided by Potomac Center for Medical Education, Postgraduate Institute for Medicine and Rockpointe Oncology
This activity is supported by independent educational grants from AstraZeneca, Genentech, Lilly, and Novartis Pharmaceuticals Corporation. For further information concerning Lilly grant funding visit www.lillygrantoffice.com.