Precision Skin Cancer Diagnosis: Gene Expression Profiling for Melanoma and cSCC

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Release Date: September 30, 2022
Expiration Date: September 30, 2023

Early detection and appropriate, risk-adjusted treatment is essential to ensure optimal outcomes for patients diagnosed with skin cancers such as melanoma and cutaneous squamous cell carcinoma (cSCC). Unfortunately, diagnosis of these malignancies can be challenging, and many patients are not diagnosed until later stages of disease. Once a patient is diagnosed, determining their risk status is particularly important, as it has major implications for treatment selection. Failure to appropriately assess patient risk can lead to either over or undertreatment, negatively impacting patient outcomes. In recent years, novel gene expression profiling (GEP) technologies designed to aid in diagnosis and risk assessment have emerged for melanoma and cSCC, and many more are in development. Use of these tests can help dermatology clinicians, including nurse practitioners and physician assistants in early identification of patients with high-risk disease who may require a more aggressive treatment approach.

This activity, Precision Skin Cancer Diagnosis: Gene Expression Profiling for Melanoma and cSCC, will review emerging trends in diagnosis and risk stratification for patients with common skin cancers. This will include practical discussion of how to improve diagnosis of melanoma and new strategies to improve risk stratification for melanoma and cSCC.

Welcome and Introductions
Gene Expression Profiling for Melanoma Diagnosis
Refining Risk Stratification in Melanoma and cSCC
Questions and Answers

For a full transcription of the program, please click here.


 Sylvana Brickley, DNP, FNP-BC, DCNP
 Lahey Dermatology
 Burlington, MA

Sylvana Brickley, MSN, FNP-BC, DCNP is a is a Dermatology Certified Nurse Practitioner and practices general medical dermatology. She earned her BSN and MSN/FNP at Simmons University in Boston, MA, then completed a two-year formal dermatology nurse practitioner postgraduate training program at University of Rochester Medical Center in Rochester, NY. She is a Clinical Associate at the University of Rochester School of Nursing and enjoys mentoring nurse practitioner students interested in dermatology. She has authored several peer-reviewed published journal articles. In addition, she serves as an Editorial Board Member for the Journal of the Dermatology Nurses' Association (JDNA) and is currently completing a two-year term as an elected Director on the Dermatology Nurses' Association Board of Directors. In her spare time, she enjoys spending time with her family, hiking, and snowboarding.

 Aaron S. Farberg, MD, FAAD
 Medical Director
 Derm Texas
 Dermatology Research Institute
 Assistant Professor
 Baylor Scott & White Health System
 Dallas, TX

 Aaron S. Farberg, MD, FAAD is a double-board certified dermatologist and micrographic dermatologic surgeon in Dallas, Texas. He is an Assistant Professor in the Section of Dermatology at Baylor Scott & White Health System. Dr. Farberg also trained in plastic and reconstructive surgery at the University of Michigan prior to a clinical research fellowship in skin cancer through the National Society for Cutaneous Medicine. In addition to treating patients, Dr. Farberg has been a clinical investigator on numerous studies including FDA clinical trials. He has been recognized with various awards and honors, including taking first place on several occasions at regional and national medical conference competitions. Dr. Farberg is an accomplished author and has published over 100 articles in professional medical journals. While in New York he served as a consultant dermatologist for the New York Yankees.

 Cynthia Griffith, MPAS, PA-C
 Physician Assistant University of Texas Southwestern Medical Center
 Department of Dermatology
 Editor in Chief Journal of Dermatology Physician Assistants
 Dallas, TX

Cynthia Griffith, MPAS, PA-C is a Dermatology Physician Assistant at the University of Texas Southwestern Medical Center in Dallas, Texas. Cynthia is the co-creator of a High Risk Skin Cancer Transplant clinic for patients who are immunosuppressed after solid organ or bone marrow transplant. She also practices general adult medical dermatology. Cynthia is the Editor in Chief for the Journal of Dermatology Physician Assistants and is a guest lecturer in the UT Southwestern PA program and a lecturer at local, regional, and national conferences. She is a member of the Texas Academy of Physician Assistants, the Society for Dermatology Physician Assistants, and the American Academy of Physician Assistants. Cynthia was awarded the UT Southwestern’s PA of the year in 2017 and 2020 America’s Top PA of 2020 awarded by Point of Care Network. When not practicing, Cynthia is a national champion dinghy sailor and marathoner.

 Sherrif F. Ibrahim, MD, PhD
 Associate Professor of Dermatology
 University of Rochester Medical Center
 Rochester, NY

Sherrif F. Ibrahim, MD, PhD is a double board-certified dermatologist and Mohs surgeon and a fellow of the American Academy of Dermatology and American College of Mohs Surgery. He is the founder of Rochester Dermatologic Surgery and an Associate professor of Dermatology at the University of Rochester Medical Center. He completed residency training at the University of Rochester followed by a fellowship in Mohs surgery, facial reconstruction, laser surgery, and cosmetic dermatology at the University of California, San Francisco. He is passionate about the treatment of all types of skin cancer and is involved in the most cutting-edge aspects of care and research. He acts as a national key opinion leader for many therapeutic areas and helps bring these new advances to mainstream care. Dr. Ibrahim publishes regularly in all major skin cancer-related journals, lectures nationally and has performed over 15,000 Mohs surgery cases. He is a national trainer in the use of minimally invasive, rejuvenating techniques to shape and contour the face. He is also a member of scientific advisory boards of cosmetic and pharmaceutical corporations, allowing him exclusive access to the newest developments, treatments, and technologies.

The intended audience for this educational initiative is physicians, physician assistants, and nurse practitioners, clinicians who are often involved in the diagnosis and initial assessment of skin cancer.

At the conclusion of an activity, participants should be able to:
  • Evaluate current and emerging clinical trial data for gene expression profiling in melanoma diagnosis
  • Identify high‐risk patients with melanoma based on the latest staging systems and gene expression profiling
  • Discuss the utility of emerging gene expression profiling assays for risk stratification of cSCC
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Potomac Center for Medical Education and Rockpointe. The Potomac Center for Medical Education is accredited by the ACCME to provide continuing medical education for physicians.

The Potomac Center for Medical Education designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

For questions regarding CME credit or the evaluation, please email

This activity is approved for 1.0 contact hour(s) of continuing education (which includes 0 hour(s) of pharmacology) by the American Association of Nurse Practitioners®. Activity ID# 22095768. This activity was planned in accordance with AANP Accreditation Standards and Policies.

This activity has been reviewed by the AAPA Review Panel and is compliant with AAPA CME Criteria. This activity is designated for 1 AAPA Category 1 CME credits. Approval is valid from 9/30/2022 to 9/30/2023 . PAs should only claim credit commensurate with the extent of their participation. AAPA reference number: CME-208016.

Potomac Center for Medical Education (PCME) adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other relevant professional organizations, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous.

All persons in a position to control the content of an accredited continuing education program provided by the Potomac Center for Medical Education are required to disclose to PCME all financial relationships with any ineligible company within the past 24 months. All financial relationships reported are identified as relevant and mitigated by PCME in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by PCME to assure objectivity and that the activity is free of commercial bias. All relevant financial relationships have been mitigated by PCME.

Faculty, Authors, and Content Developers
The faculty, authors and content developers reported the following relevant financial relationships with ineligible companies:

Sylvana Brickley, DNP, FNP-BC, DCNP: has no relevant financial relationships

Aaron S. Farberg, MD, FAAD: Consulting Fee: Amgen, Castle Biosciences, Galderma, Incyte, Novartis, Pfizer, Sun Pharmaceuticals, Ortho-Dermatologics

Cynthia Griffith, MPAS, PA-C: has no relevant financial relationships 

Sherrif F. Ibrahim, MD, PhD: Consulting Fee: Castle, Galderma, Regeneron; Contracted Research: Biofrontera, Castle, Galderma, Regeneron, Replimune; Honoraria: Castle, Genentech, Regeneron; Speakers' Bureau: Castle, Genentech, Regeneron

Planners and Managers
The planners and managers reported the following relevant financial relationships with ineligible companies:  

Chelsey Goins, PhD: has no relevant financial relationships

Content Reviewers
The content reviewers reported the following financial relationships with ineligible companies:

Katie Propst, PhD: has no relevant financial relationships

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There is no fee for this activity. To receive credit, participants must take the pre-test, view this CME activity in its entirety, and then complete the post-test, with a score of 70% or better, and evaluation. The estimated time for completion of this activity is 1 hour. To receive their certificates, participants must demonstrate mastery of the presented material via the post-test. Participant is allowed to take the post-test multiple times.

Jointly provided by the Potomac Center for Medical Education and Rockpointe


This activity is supported by an educational grant from Castle Biosciences, Inc.

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